A major difference between Hodgkin's lymphoma and non-Hodgkin's lymphoma is that:

A major difference between Hodgkin's lymphoma and non-Hodgkin's lymphoma is that:

• A. Hodgkin's lymphoma occurs only in young adults.
• B. Hodgkin's lymphoma is considered potentially curable.
• C. Non-Hodgkin's lymphoma can manifest in multiple organs.
• D. Non-Hodgkin's lymphoma is treated only with radiation therapy.

Answer: (C)

The main idea is how the diseases spread and what organs they involve. Hodgkin's lymphoma typically presents with painless enlarged lymph nodes and tends to spread in a contiguous, orderly way through the lymphatic system, often staying localized to nodal regions at first. Non-Hodgkin's lymphoma can involve lymph nodes but more commonly shows extranodal involvement, affecting multiple organs such as the stomach, liver, bone marrow, or CNS from the outset. That ability to manifest in several organs is the defining difference between the two. Other statements aren’t the best distinction: Hodgkin's can occur outside young adulthood, and while it is often curable with treatment, many NHL subtypes are also curable and treatment isn’t limited to radiation alone.

The main idea is how the diseases spread and what organs they involve. Hodgkin's lymphoma typically presents with painless enlarged lymph nodes and tends to spread in a contiguous, orderly way through the lymphatic system, often staying localized to nodal regions at first. Non-Hodgkin's lymphoma can involve lymph nodes but more commonly shows extranodal involvement, affecting multiple organs such as the stomach, liver, bone marrow, or CNS from the outset. That ability to manifest in several organs is the defining difference between the two. Other statements aren’t the best distinction: Hodgkin's can occur outside young adulthood, and while it is often curable with treatment, many NHL subtypes are also curable and treatment isn’t limited to radiation alone.