NCLEX Hematology Practice Test

These questions are part of the practice quiz. Start practicing

• A patient with sickle cell anemia says they are planning a ski trip to a high-altitude area. The nurse assesses for the need for further instruction when the patient states:
• The intrinsic factor essential for vitamin B12 absorption is produced by the lining of which organ?
• Which smear finding is commonly seen in chronic lymphocytic leukemia?
• What is an immediate action if an acute hemolytic transfusion reaction is suspected?
• A 20-year-old woman with sickle cell trait asks about its inheritance. Which statement is correct?
• What is the typical initial therapy goal in polycythemia vera to reduce thrombosis risk?
• If an allergic transfusion reaction is suspected, what is the first action the nurse should take?
• During the start of a blood transfusion, for how many minutes should the nurse stay with the patient?
• Before administering a transfusion of packed red blood cells, what essential check must be performed?
• In multiple myeloma, what does M-protein indicate?
• In a patient with disseminated intravascular coagulation (DIC), which medication should the nurse anticipate administering?
• Before giving a transfusion of packed red blood cells, what safety step should the nurse perform?
• A patient with von Willebrand disease undergoing surgery would be treated with replacement therapy including von Willebrand factor and which coagulation factor?
• The presence of which cells indicates Hodgkin's lymphoma?
• A patient develops hemolytic anemia after penicillin; what is the most appropriate description?
• In a patient with thrombocytopenia, which dental hygiene practice helps reduce gum bleeding?
• Which nursing measures are important for a patient with thrombocytopenia?
• What are the CRAB features of multiple myeloma?
• For pernicious anemia, which statement reflects appropriate long-term management?
• What are the hallmark features and initial management of transfusion-related acute lung injury (TRALI)?
• Which statement best describes essential patient education for someone on warfarin therapy?
• A major difference between Hodgkin's lymphoma and non-Hodgkin's lymphoma is that:
• In polycythemia vera, which treatment is used for high-risk patients to reduce thrombotic risk?
• What is commonly seen as the initial presentation of Hodgkin lymphoma?
• In adults with ITP and severe mucosal bleeding, which treatment is used for acute control?
• How does non-Hodgkin lymphoma typically present and how is it treated?
• In an 83-year-old patient with an infection, which laboratory finding would the nurse expect?
• What is the purpose of starting a new saline infusion after stopping the transfusion due to a reaction?
• Induction therapy for acute lymphocytic leukemia (ALL) is described as a:
• In suspected transfusion reaction, what is the initial action?
• A preoperative teaching for autologous donation before scheduled surgery: which statement is correct?
• In polycythemia, the increased blood viscosity most commonly predisposes patients to which complication?
• Which patient population is most commonly diagnosed with chronic lymphocytic leukemia?
• Which beverage is most likely to enhance iron absorption when taken with iron supplements?
• Disseminated intravascular coagulation (DIC) is best described as:
• A nurse in a clinic is evaluating a client for suspected anemia. Which laboratory result would indicate anemia?
• Which option is not a treatment for non-Hodgkin's lymphoma?
• In disseminated intravascular coagulation (DIC), which laboratory finding indicates depletion of clotting factors?
• In iron deficiency anemia, what is ferritin level?
• In disseminated intravascular coagulation, what is the mechanism by which heparin can be beneficial?
• One of the most elementary home interventions to help prevent a sickle cell crisis is to which of the following?
• Which of the following foods is a rich source of iron and often recommended for a patient with iron deficiency anemia?
• In non-Hodgkin's lymphoma, lymph node enlargement is typically:
• What vaccination strategy is important for individuals without a spleen (asplenia)?
• What does blast crisis signify in chronic myeloid leukemia?
• Which statement correctly describes the initial management of a suspected transfusion reaction?
• Which statement about sickle cell trait inheritance is accurate?
• Which lab pattern differentiates iron deficiency anemia from thalassemia trait?
• If a lymph node is palpated, what is a normal finding?
• What should be documented after a suspected transfusion reaction occurs?
• Which statement best describes precipitants of a vaso-occlusive crisis in sickle cell disease?
• Which transfusion-related complication can be reduced by leukocyte depletion or reducing RBC transfusion volume?
• After stopping the transfusion, what is the next step in management?
• Pernicious anemia is a macrocytic anemia characterized by which finding?
• Significant information obtained from the patient’s health history relating to the hematologic system includes which finding?
• Why can ferritin be misleading in iron studies during infection or inflammation?
• After stopping the transfusion due to a suspected reaction, which fluid should be started to maintain vein patency?
• A nurse is teaching a client about a iliac crest bone marrow biopsy. Which statement indicates understanding?
• Pernicious anemia is caused by a deficiency of which nutrient due to loss of intrinsic factor?
• Why are individuals without a spleen at increased risk for severe infection?
• A client is on warfarin therapy. Which laboratory value indicates a need to increase the dosage?
• In adults with mild von Willebrand disease presenting with mild bleeding, what is the initial treatment?
• Nursing interventions for severe anemia related to peptic ulcer disease should prioritize which action?
• What are key nursing steps immediately after a bone marrow biopsy?
• What is the clinical hallmark of heparin-induced thrombocytopenia and its management?
• What are the signs of febrile non-hemolytic transfusion reaction and its management?
• Which finding indicates successful treatment of pernicious anemia?
• Why are multiple drugs often used in combination to treat leukemia and lymphoma?
• Which CBC pattern is typical of iron deficiency anemia?
• Which of the following is a risk factor for heparin‑induced thrombocytopenia (HIT)?
• In iron deficiency anemia, the red blood cells are typically described as which combination of color and size?
• What is the commonly used threshold for prophylactic platelet transfusion in a nonbleeding patient?
• Which practice best supports optimal iron absorption when taking ferrous sulfate?
• Which statement about lymph node examination is true?
• What preventive measures are important to reduce TLS risk during cancer therapy?
• In a severely anemic patient, which finding would you most likely expect?
• Which statement about autologous donation is true?
• Which finding is characteristic of thrombotic microangiopathy such as TTP?
• During a bone marrow biopsy of the iliac crest, which position allows access to the site?
• What is the marrow finding in aplastic anemia?
• Which pattern is most typical of DIC on lab evaluation?
• Which statement about managing DIC is accurate?
• What is the pathophysiology of pernicious anemia?
• Which action should be taken first when a transfusion reaction is suspected?
• Which finding best confirms autoimmune hemolytic anemia?
• In immune thrombocytopenia (ITP) with mucosal bleeding in adults, which treatment is commonly used as initial therapy?
• When obtaining data from a patient with microcytic, hypochromic anemia, which history item would you question?
• When assessing the lymph nodes, which technique is appropriate?
• What is the purpose of collecting blood and urine specimens during suspected transfusion reaction?
• Which IV solution should be used with blood products?
• Deficiency of iron in the diet leads to which hematologic reduction in iron deficiency anemia?
• Which finding indicates a febrile transfusion reaction during a unit of packed RBCs?
• A nurse is preparing to administer packed RBCs to a client with Hgb 8 g/dL. Which action should be performed during the first 15 minutes of the transfusion?
• A nurse is caring for a patient with sickle cell anemia and emphasizes foot and leg care. Which statement reflects a key concern?
• What are the key laboratory findings in disseminated intravascular coagulation?
• Which statement correctly differentiates TRALI from TACO and their management?
• Warfarin interferes with prothrombin production, thereby altering the clotting mechanism during which process?
• The home health nurse caring for a patient with polycythemia vera should focus on which aspect of care?
• Which sign would a nurse expect to find in a patient with a hematologic disorder in which microvascular clotting is occurring?
• A nurse assessing a client with DIC should anticipate which physical finding?
• Which statement about asplenia vaccination is accurate?
• Which drug is classically associated with aplastic anemia?
• In assessing a patient with polycythemia vera, which finding would the nurse anticipate?
• In suspected febrile neutropenia, which actions are performed first?
• If a transfusion reaction is suspected, what should be done with unused blood and blood tubing?
• Which action is performed as part of essential pretransfusion nursing actions, with the best practice being the two-nurse check?
• An individual who lives at a high altitude may normally have an increased RBC count because
• What is the pneumococcal vaccination schedule for asplenia?
• Which statement best distinguishes TTP from HUS and indicates the main treatment?
• Which specimens are collected and sent to the laboratory during a suspected transfusion reaction?
• Which therapy is commonly used in non-Hodgkin's lymphoma, exploiting targeted immune mechanisms?
• In sickle cell disease, what is the primary focus in management of an acute chest syndrome?
• A complication associated with polycythemia due to hyperviscosity is which of the following?
• Which of the following is true about tumor lysis syndrome prevention?
• What neurologic finding helps differentiate folate deficiency from B12 deficiency?
• What is the hallmark cell in Hodgkin lymphoma and a common clinical feature?
• In thalassemia trait, RBC count is typically what in relation to Hb?
• A home health nurse is teaching a patient taking ferrous sulfate. Which patient statement indicates teaching is needed?
• Which laboratory findings support hemolysis in autoimmune hemolytic anemia?
• In mild von Willebrand disease with mucosal bleeding, which medication should be avoided to reduce bleeding risk?
• Which symptom is commonly associated with a transfusion reaction and warrants stopping the transfusion?
• Which statement is a transplantation option used in non-Hodgkin's lymphoma management?
• In the event of a suspected transfusion reaction, what describes the correct overall management sequence?
• How does hypersplenism affect blood counts and what precaution is important after splenectomy?
• Pernicious anemia differs from aplastic anemia in that pernicious anemia results from a lack of intrinsic factor leading to poor absorption of vitamin B12, whereas aplastic anemia is primarily due to:
• What are the defining features of aplastic anemia?
• Which laboratory test confirms a suspected transfusion reaction?
• Exposure to cold temperatures and high altitudes can precipitate a sickle cell crisis primarily due to which mechanism?
• A nurse preceptor is observing a newly licensed nurse preparing to administer a blood transfusion to an older adult. Which action indicates understanding?
• Which statement describes triggers and avoidance for hemolysis in G6PD deficiency?
• Malignant disorders that arise from granulocytic cells in the bone marrow will have the primary effect of causing
• The nursing management of a patient in sickle cell crisis includes which primary actions?
• Which peripheral smear findings are typical of iron deficiency anemia?
• Which condition is associated with immune thrombocytopenia (ITP) rather than HIT?
• Which of the following foods is NOT a good source of iron?
• When a transfusion reaction is suspected, what should be done with the blood bag and tubing?
• When preparing to administer a transfusion to an older adult, which verification should be performed?
• Postbone marrow biopsy nursing care includes which single most essential action?
• Which statement correctly describes PT/INR and aPTT in coagulation assessment?
• In suspected transfusion reaction, which action helps verify correct transfusion product and patient identity?
• Which statement best describes uric acid–lowering therapy used in TLS prevention?
• A bone marrow biopsy is performed to assess which of the following?
• For a patient with thrombocytopenia, which instruction should the nurse emphasize to minimize bleeding risk?
• The patient with acute myeloid leukemia asks why there are more white cells when the count is already high. The nurse explains that the leukemic cells:
• During a transfusion reaction, what is the first action the nurse should take?
• Which peripheral smear findings are typical in thalassemia major and intermedia?
• Who should be notified immediately when a transfusion reaction is suspected?
• What is the most common cause of iron deficiency anemia in adults?
• How is ANC calculated in this context?
• What is a commonly used RBC transfusion threshold for a stable adult without active coronary disease?
• Which test helps differentiate a factor deficiency from a factor inhibitor in hemophilia patients?
• A patient’s CBC shows WBC 6.5 × 10^3/µL, Hgb 13.4 g/dL, Hct 40%, Platelets 50 × 10^3/µL. What is the primary concern?
• What is the main treatment for TTP/HUS?
• What does an elevated reticulocyte count indicate in anemia?
• Which statement correctly identifies an indication for erythropoiesis-stimulating agents (ESAs)?
• Which is a known risk associated with ESAs?
• Which clinical scenario best indicates a risk for HIT?
• During a transfusion reaction, what ongoing nursing action should be performed?
• After a bone marrow biopsy, which action should the nurse emphasize as part of post‑procedure care?
• In a patient with thrombocytopenia due to AML, which action is contraindicated?
• The most common type of leukemia in older adults is:
• Which INR value is considered therapeutic for many conditions on warfarin?
• Which neurologic findings are commonly associated with vitamin B12 deficiency?
• What Hb variant is implicated in sickle cell disease and what triggers sickling?
• In the care of a patient with thrombocytopenia, which action reduces bleeding risk?
• Which statement compares AML and ALL regarding typical age group and blasts on smear?
• In a patient who recently had a gastrectomy, which type of anemia is of concern due to lack of intrinsic factor?
• Polycythemia vera commonly presents with which skin finding?
• What is the long-term treatment approach for thalassemia major?
• During a suspected transfusion reaction, what is the first action the nurse should take?
• What is the primary reason for staying at the bedside during the initial phase of a blood transfusion?
• What describes the typical presentation of chronic lymphocytic leukemia?
• Hodgkin's lymphoma is often considered to be:
• Which action helps verify correct transfusion product and patient identity when a reaction is suspected?
• A client with idiopathic thrombocytopenic purpura (ITP) should report possible small‑vessel clotting when which finding is assessed?
• Which strategy best prevents tumor lysis syndrome during cancer treatment?
• In DIC, what is a consequence of clotting factor depletion?
• What are the consequences of chronic iron overload and how is it treated?
• For a client with leukemia and thrombocytopenia, what is the priority action for the nurse?